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KMID : 0545120040140061338
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Journal of Microbiology and Biotechnology
2004 Volume.14 No. 6 p.1338 ~ p.1342
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Cyclosophoraose as a Novel Chiral Stationary Phase for Enantioseparation
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Jung YJ
Lee SH/Paik SR/Jung SH
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Abstract
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Cyclosophoraoses (Cys) cyclic β-(1→2)-D-glucans produced by Rhizobium meliloti 2011 were used as a novel chiral stationary phase for the enantiomeric separation. A novel Cys stationary phase chemically immobilized onto porous silica via aminopropyltrimethoxysilane as a molecular linker showed good separation for each racemate of bupivacain (separation factor α=1.3) propranolol (α=1.3) and fenoprofen (α=2.9) respectively under the mobile phase of water: methanol (80:20 v/v) at a constant flow rate of 0.9 ml/min at pH 7.
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